L. G. Leijssen1,2, A. M. Dinaux1,2, C. R. Ferrone1,2, H. Kunitake1,2, L. G. Bordeianou1,2, D. L. Berger1,2 1Massachusetts General Hospital,General And Gastrointestinal Surgery,Boston, MA, USA 2Harvard School Of Medicine,Brookline, MA, USA
Introduction: ?Concomitant hepatectomy in patients with primary colon cancer and synchronous liver metastasis is feasible. The aim of this study is to assess the impact of combined hepatectomy and colectomy compared to separate procedures on both short- and long-term outcomes.?
Methods: All patients who underwent a hepatectomy for metastatic colon cancer at our tertiary center from 2004 to 2014 were included. We compared patients who underwent hepatectomy during (DC) with before or after colectomy (BAC) and partial (PH) against extended hepatectomy (EH). ?
Results: We included 18 DC and 44 BAC patients (6.3% before and 63.5% after colectomy). DC patients had more transverse tumors (P=0.009), less sigmoid cancer (P=0.047), and a higher readmission rate (P<0.001). EH was performed in a comparable numbers of patients (DC 61.1% vs. BAC 61.4%). Mean survival duration was non-significantly shorter for DC patients (36 vs. 48 months; P0.075). R0 resection was achieved in 91.7% of PH and 97.4% of EH patients (P=0.308). Mean survival duration was non-significantly shorter for EH patients (49 vs. 42 months; P0.298). In adjusted analyses, there was no difference in overall survival between DC and BAC patients (HR 1.126 [95% CI: 0.46-2.76] P=0.795), or PH and EH patients (HR 1.042 [95% CI: 0.46-2.36] P=0.921).?
Conclusion: This study underscores the oncologic safety of simultaneous hepatectomy in patients with primary colon cancer and synchronous liver metastasis.?
