T. Cheung1, W. Dai1, S. H. Tsang1, W. She1, A. C. Chan1, K. S. Chok1, C. Lo1 1The University Of Hong Kong,Hong Kong, HONG KONG, Hong Kong
Introduction:
Survival of patients with carcinoma of the breast with liver metastases is very poor. This study aimed to analyze the survival outcome of hepatic resection for this patient population.
Methods:
From January 1995 to December 2014, 773 patients with (Non HCC) liver cancer received hepatectomy at our hospital. Twenty-one of them, all female, received the operation for breast cancer liver metastases. Performance were compared with patients with colorectal liver metastases treated with hepatectomy after propensity score analysis in a ratio of 1:3.
Results:
Twenty one patients received hepatectomy for breast cancer. After propensity score matching, sixty three patients who had hepatectomy for colorectal cancer were selected for comparison. There was no significant different in immediate short term outcome between the 2 groups of patients in term of operation time, blood loss and surgical morbidities. All patient with breast cancer had R0 resections. No hospital death occurred. After hepatectomy, the 1-year, 3-year and 5-year survival rate was 100%, 58.9% and 58.9% in patients with CA breast. The 1-year, 3-year and 5-year survival rate was 95%, 57.2% and 39.7% respectively in patients with CA colon (p=0.572). Multivariate analysis showed that all PR, ER and HER negative was an independent significant factor for poor survival (p=0.027; hazard ratio, 5.58; confidence interval, 1.21-25.73).
Conclusion:
Hepatic resection is a safe and effective treatment for breast cancer liver metastases. It should be considered more frequently as part of the multidisciplinary care for this patient population.
