A. Ayub1, S. Rehmani1, A. Al Ayoubi1, W. Raad1, J. McGinty2, G. Kim2, F. Y. Bhora1 1Mount Sinai School Of Medicine,Division Of Thoracic Surgery / Department Of Surgery / Mount Sinai West,New York, NY, USA 2Mount Sinai School Of Medicine,Department Of Surgery / Mount Sinai West,New York, NY, USA
Introduction: Primary Non-Hodgkin lymphoma of the gallbladder (PNHLGB) is extremely rare with limited available data. In this study, we sought to evaluate the clinical features and outcomes of patients with PNHLGB utilizing a population-based database.
Methods: Surveillance, Epidemiology, and End Results (SEER) database was queried for patients with gallbladder cancer between 1973 and 2013. Only patients with histologically proven PNHLGB were included. Demographics, tumor characteristics, and outcomes were assessed.
Results: Of 150 gallbladder lymphomas in the SEER database, 106 cases had PNHLGB and were included in the study. The mean age at diagnosis was 71 (±15) years. PNHLGB primarily afflicted whites (92%) with a male: female of 1.03: 1. Diffuse large B-cell lymphoma (DLBCL) was the most common histological subtype (33%); majority (61%) had loco-regional disease. Surgical resection was performed in 85% cases. Median overall survival of the whole cohort was 41 months with a 5-year survival rate of 40%. In multivariate analysis, increasing age at diagnosis (p<0.001) was associated with increased hazards of death, surgical resection had a protective effect (p=0.007), while gender, race, tumor histology and disease stage were not associated with overall survival (Figure).
Conclusion: This study represents the largest series of PNHLGB to be reported. Compared to other gastrointestinal lymphomas reported in the literature, PNHLGB appears to have worse prognosis and surgical resection provides survival benefit. Further studies with information regarding adjunctive therapies are warranted.
