J. Ousley1, J. A. Castellanos1, C. E. Bailey1, N. Baregamian1 1Vanderbilt University Medical Center,General Surgery,Nashville, TN, USA
Introduction: The incidence of pancreatic neuroendocrine tumors (PNET) is rising, but little is known about the impact of disparities on survival. The aim of our study was to characterize existing disparities in patients with PNET.
Methods: A retrospective cohort study of patients diagnosed with PNET was performed using the Surveillance, Epidemiology, and End Results (SEER) database between 1988-2012. Kaplan-Meier and log-rank test were used for survival analysis. A multivariable (MV) logistic regression model was used to assess demographic and tumor-related factors associated with survival.
Results: A total of 3,759 patients with PNET were identified. The mean age at diagnosis was 57.7 + 13.9 years. The majority of patients were male (54%), white (80.5%), married (64.2%), and presented with distant disease (55.4%). Median overall survival (OS) for the entire cohort was 52 months. Median OS was significantly improved for patients who underwent primary tumor resection (PTR) compared to those who did not (64 vs 29 months, p<0.001). On MV analysis, increasing age, male sex, higher grade tumors, and increasing stage were associated with worse survival, whereas tumor location in the tail of the pancreas and PTR were associated with improved survival (Table).
Conclusion: Significant survival disparities were found in a cohort of patients with PNET, with improved survival observed in patients who underwent primary tumor resection. Future studies focusing on access to care, patient education, and socioeconomic factors may help elucidate key factors for improved survival in patients with PNET.
