A. Alhefdhi1,2, T. AlTayyar1, M. Alshehri1,2, S. Alqahtani3, S. ALSobhi1,2, A. Alhefdhi1,2 1King Faisal Specialist Hospital & Research Center,General Surgery/Breast And Endocrine Surgery,Riyadh, RIYADH, Saudi Arabia 2Alfaisal University,General Surgery/Breast And Endocrine Surgery,Riyadh, RIYADH, Saudi Arabia 3Al Majmaah University,Al Majmaah,Al Majmaah, RIYADH, Saudi Arabia
Introduction: Atypia of Undetermined Significance (AUS) and Follicular Lesion of Undetermined Significance (FLUS) is a heterogeneous group, in which it is difficult to classify as benign, suspicious or malignant. This study aimed to identify any correlation between patients’ demography (age, gender), ultrasound variables, nodule size, preoperative serum thyroglobulin (Tg), and anti-thyroglobulin antibodies (TgAb) levels and the final pathology (benign vs. malignant).
Methods: A 6-year retrospective review conducted, including all patients diagnosed with AUS or FLUS at a single institution.
Results: Fifty cases were identified with a mean age of 41±12 years. The majorities were females 35(70%). The mean size of the largest thyroid nodule based on the preoperative ultrasound was 38±24mm. Moreover, the median value of the serum TG, and TgAb were 106 (0.4-3385) ug/L, and 16(9-4100) U/ml retrospectively. The mean of the thyroid stimulated hormone (TSH) was 1.83±1.2 mU/L. The majority of the final pathology on 28(56%) cases demonstrated malignancy, and 22 (44%) cases showed benign pathology. There was no difference between those who have a benign pathology or the malignant pathology in form of age, gender, TG, TgAb, and TSH levels, or the preoperative size of the thyroid nodule.
Conclusion: Based on our data; in our population; almost half of the patients who found to have AUS or FLUS from the thyroid nodule FNA, found to have a malignancy in the final pathology report.