H. Khadra1, T. Cushing1, S. Souza1, J. Crowther1, C. DuCoin1 1Tulane University School Of Medicine,Department Of Surgery,New Orleans, LA, USA
Introduction:
Conflicting data in the literature have reported the increased risk of esophageal and gastric adenocarcinoma after cholecystectomy. The purpose of this study was to determine if there is a risk of esophageal or gastric adenocarcinoma after cholecystectomy by performing a meta-analysis of the current literature.
Methods:
Independent reviewers conducted a systematic review of publications from PubMed, EMBASE, and the Cochrane Database of Systematic Review using the following keyword searches: “esophageal adenocarcinoma and cholecystectomy,” “gastric adenocarcinoma and cholecystectomy,” “gastric cancer and cholecystectomy,” and “esophageal cancer and cholecystectomy.” Additional articles were retrieved by manual search of references. Studies reported either odds ratios or relative risks, which were treated as equivalent in the analysis since both values will be similar for diseases with low incidence. If a study provided both univariate and multivariate-adjusted relative risks, the multivariate-adjusted values were used.
Results:
33 publications were identified and seven studies met our inclusion criteria. The studies included spanned between 13-43 years. Cholecystectomy was not found to be associated with an increased risk of esophageal adenocarcinoma (RR 1.11; 95%CI: 0.87-1.40), nor was it associated with an increased risk of gastric adenocarcinoma (RR-1.06; 95%CI: 0.91-1.23).
Conclusion:
The results of this meta-analysis suggest that cholecystectomy does not increase the risk of esophageal or gastric adenocarcinoma.