S. R. Kaslow1, C. Cartier1, M. L. Plasilova1 1New York University Langone Health,Department Of Surgery,Brooklyn, NY, USA
Introduction:
Multiple studies have associated increased body mass index (BMI) with more aggressive breast cancer tumor biology and worse clinical outcomes, however, many of these studies were conducted with primarily non-Hispanic white patients. We aimed to compare the clinical outcomes and breast cancer tumor biology of patients with increased BMI (≥25) and normal BMI (18-25) at New York University Langone Health (NYULH), which serves a racially and ethnically diverse patient population.
Methods:
We extracted data on geography, race/ethnicity, breast cancer recurrence rates, and tumor biology from the NYULH Institutional Breast Cancer Database, which contains sociodemographic and clinical information for breast cancer patients who received first definitive surgery at New York University Langone Medical Centers in Manhattan and Brooklyn.
Results:
Our data included 3,091 patients with invasive breast cancer and ductal carcinoma in situ. Breast cancer patients living in Brooklyn had increased BMI compared to breast cancer patients living in Manhattan (p=0.013). There was no statistically significant difference in breast cancer recurrence in patients with increased BMI relative to those with normal BMI (p>0.5). Our data show a higher proportion of ethnic minorities diagnosed with breast cancer in Brooklyn compared to Manhattan, including African Americans (35.2% vs. 17.6%) and Asian Americans (12.1% vs. 8.5%). We did not find a significant difference in breast cancer recurrence when comparing White and non-White patients with increased BMI.
Conclusion:
Despite differences in ethnic minority status between two study sites and statistically significant differences in BMI based on residence, breast cancer patients treated within NYULH with increased body mass index did not have statistically significant different breast cancer recurrence rate.