M. Gunder1, S. Kumar1, K. Lau1, A. Di Carlo1, S. Karhadkar1 1Temple University,Surgery,Philadelpha, PA, USA
Introduction:
Delayed graft function (DGF) is defined as the need for dialysis within seven days of kidney transplant. DGF has long been associated with increased risk of graft failure and decreased overall survival. Several studies have identified risk factors for DGF, focusing on donor characteristics. There is little data about the role of recipient characteristics in predicting DGF.
Methods:
A retrospective review of consecutive kidney transplant recipients performed at a single institution from 2013-2018 was conducted. Data was collected on recipient variables, as well as on donor factors including KDPI, and the incidence of delayed graft function. Paired t-test or Fisher exact test was used to assess correlation between each variable and DGF.
Results:
A total of 199 patients underwent renal allotransplantation at our institution during the time period described. 72 patients in total had delayed graft function (36.18%). Factors found to correlate with increased rate of DGF include KDPI >50 (p=0.0340), time on dialysis >1600 days (p=0.0433), presence of recipient peripheral vascular disease (p=0.0336), recipient age >58 (p=0.0138), and recipient independence score <50% (p=0.0033).
Conclusion:
Delayed graft function occurs secondary to a multifactorial process therefore a predictive model must include both recipient and donor factors. We identified 5 separate variables that correlated with DGF after kidney transplantation. Identification of risk factors for DGF will help tailor induction immunosuppression protocols to maximize allograft function.