56.10 Male vs. Female Patients with Breast Intraductal Papilloma Based on One Tertiary Center Experience

Posted on September 9, 2020

R. K. Almesned3, R. Alsalamah1, S. M. AlHashim2, A. Tulbah1,4, A. Alefdhi1,3  1King Faisal Specialist Hospital & Research Center,Breast And Endocrine Surgery,Riyadh, RIYADH, Saudi Arabia 2King Faisal Specialist Hospital & Research Center,Department Of Biostatistics, Epidemiology, And Scientific Computing,Riyadh, RIYADH, Saudi Arabia 3Alfaisal University,Riyadh, RIYADH, Saudi Arabia 4King Faisal Specialist Hospital & Research Centre,Department Of Pathology And Laboratory Medicine,Riyadh, RIYADH, Saudi Arabia

Introduction:  Breast Intraductal papilloma (IP) is a growth due to abnormal proliferation of ductal epithelial cells. It accounts for almost 10% of benign breast lesions and around 1% of malignant breast tumors. While it occurs commonly in females aged between 35-55 years, IP is an extremely rare disease of the male breast with few case reports in the literature. Therefore, this study aimed to investigate the clinical characteristic of breast IP in male patients and to compare them with female patients based on our experience.

Methods:  Retrospective study included all cases with IP treated at single tertiary center from 2000-2018.

Results: A total of 261 observations in a total of 222 patients diagnosed with IP. Among them 8 observations (3.1%) in 6 patients (2.7%) were males. While the majority of the male patients presented with breast mass in 5 (62.5%) observations, the majority of female patients were found to have IP incidentally during the screening images in 133 (52.6%) observations (p = 0.022). The location of the masses is shown to be more common in the upper outer quadrant (UOQ) for both males and females, 3 (37.5%) and 111 (43.9%) respectively, but retro-areolar location was observed in 25% of males vs. 2.8% in females (p = 0.0219). Importantly, the association with cancer was higher in males vs. females 6 (75%) observations vs. 50 (19.76%) p-value of (0.0015). 

Conclusion: Our data suggest that males with IP tend to present with breast mass located at the UOQ and have a higher incident of cancer association.