R.A. Castro1, M. Azuma1, L.W. Graeff1, H. Kehara1, K. Krishan1, R. Yanagida1, M.A. Kashem1, Y. Toyoda1 1Temple University, Division Of Cardiovascular Surgery, Philadelpha, PA, USA
Introduction:
The purpose of this study was to determine if differences in the age, height, or gender between recipients and donors of lung transplantation have an effect on survival outcomes at our institution.
Methods:
In this retrospective cohort study, we examined the demographics and outcome data of a large cohort of lung transplant donors and recipients at our institution between 2012 and 2024. Lung transplant recipients were placed into cohorts based on differences in age, gender, and height from their respective donors. Age cohorts included recipients whose age differed from their donors by more than 20 years and recipients whose age differed from their donors by 20 years or less. Gender cohorts included recipients whose gender was the same as their donors and recipients whose gender was different from their donors. Height cohorts included recipients whose height differed from their donors by more than 6 inches and recipients whose height differed from their donors by 6 inches or less. JMP Pro 17 Statistical Software was used to generate Student’s T-tests that evaluated the demographic, diagnostic, and procedural differences within our cohort of patients. Kaplan-Meier survival curves were generated using JMP Pro 17 to assess for differences in the seven-year survival outcomes of lung transplant recipients within different age, gender, and height cohorts, respectively.
Results:
Our study was comprised of 1224 total lung transplant recipients (64 ± 9 years; 786 male) from our institution. Among the age cohorts, 824 recipients differed from their donors by greater than 20 years in age (66 ± 7 years; 547 male) and 388 recipients differed by 20 years or less from their donors (60 ± 11 years; 232 male). Within the gender cohorts, 795 recipients were the same gender as their donor (64 ± 9 years; 580 male) and 421 recipients were a different gender (64 ± 9 years; 202 male). Within the height cohorts, 211 recipients differed by more than 6 inches of height from their donors (65 ± 8 years; 101 male) and 1001 recipients differed by 6 inches or less from their donors (64 ± 9 years; 677 male). Upon conducting a Kaplan-Meier survival curve, there was no significant difference in survival outcomes after 7 years within the age cohorts (Χ 2 = 0.0001, df = 1, p = 0.991), gender cohorts (Χ 2 = 0.059, df = 1, p = 0.809), and height cohorts (Χ 2 = 0.148, df = 1, p = 0.701).
Conclusion:
The results of our single center retrospective cohort study showed that lung transplant recipients at our institution had comparable mortality rates over 7 years regardless of differences in age, gender, and height from their donors. This suggests that differences in age, gender, and height between lung transplant recipients and donors do not negatively impact survival outcomes.