N. R. Brand1, L. Qu2, A. Chao3, A. Ilbawi4 1University Of California – San Francisco,Surgery,San Francisco, CA, USA 2Monash University,Faculty Of Medicine, Nursing & Health Sciences,Victoria, Australia 3National Cancer Institute,Center For Global Health,Bethesda, MD, USA 4World Health Organization,Management Of Noncommunicable Diseases Unit, Department For Management Of Noncommunicable Diseases, Disability, Violence And Injury Prevention,Geneva, Switzerland
Introduction:
Of the 746,000 colorectal cancer (CRC) diagnoses made each year, the majority occur in high-income countries (HIC), while over 50% of deaths occur in low- and middle-income countries (LMIC). Stage of disease at diagnosis is a significant prognosticator of survival and the higher rates of advanced stage diagnoses made in LMIC may contribute to the difference in death rates between HIC and LMIC. This review focuses on delays and barriers to CRC diagnoses of patients in LMIC, where CRC incidence is increasing.
Methods:
We conducted a systematic review of peer reviewed literature published on these topics in LMIC. Inclusion criteria for our systematic review was any full text article that addressed barriers to care or delays in early diagnosis of CRC that was conducted in LMIC. Studies were required to contain any of the following: (i) defined or reported delay intervals in the diagnosis of symptomatic CRC or (ii) reported predictive factors or barriers that delayed early diagnosis of symptomatic CRC.
Results:
Of the 10,193 abstracts screened, 9 studies met inclusion criteria. All 9 studies were conducted in middle-income countries. Five studies assessed the intervals along the pathway from symptom onset to cancer treatment, and significant delays were identified along all stages of the cancer care continuum. All 5 studies identified that the greatest delay occurred prior to disease diagnosis. Of the 4 studies that assessed individual intervals of CRC diagnosis; 2 (50%) found the greatest delay occurred during the interval between symptom onset and presentation to the healthcare system, and 2 (50%) found the greatest delay occurred between first presentation to the healthcare system and cancer diagnosis. Six studies assessed barriers to cancer care, and 4 studies assessed knowledge of CRC. All studies found low levels of knowledge of CRC as a disease, its risk factors, or how it is diagnosed, in both the general population and among healthcare workers.
Conclusion:
Despite the increasing burden of CRC in LMIC, there is little published research on delays to CRC diagnosis and treatment or the barriers that cause them in resource-limited settings. Our review demonstrates significant delays throughout the entire process of cancer diagnosis and treatment and identifies the period prior to CRC diagnosis as the most vulnerable to delays. In addition, we have identified low levels of knowledge about CRC in both the general population and healthcare workers. Our study highlights the tremendous need for research and action to reduce CRC morbidity and mortality in LMIC.