93.14 Assessing Documentation Provided For Interhospital Transfers of Emergency General Surgery Patients

F. Harl1, M. Saucke1, C. Greenberg1, A. Ingraham1  1University Of Wisconsin,Madison, WI, USA

Introduction:  Poor communication can lead to fragmentation of care and adverse patient outcomes. Studies of transitions of care within a single hospital and at discharge suggest significant communication deficits. Communication during transfers across hospitals, which are inherently complex and at high risk for communication failures, has not been well-studied in surgical populations. This study assessed the written communication provided during interhospital transfers of emergency general surgery (EGS) patients. We hypothesize that EGS patients are often transferred with incomplete documentation of the workup, diagnosis, and treatment provided at referring facilities leading to uncertainty at the accepting hospital and wasted resources.

Methods:  We performed a retrospective review of written communication during interhospital transfers of EGS patients. Patients transferred to our institution from outside emergency departments (ED) for emergency general surgical evaluation between 4/1/14 – 3/1/16 for 6 EGS diagnoses (appendicitis, cholecystitis, diverticulitis, bowel obstruction, perforated viscus, mesenteric ischemia) as assigned by accepting providers were included. Searching the existing comprehensive electronic medical record, which incorporates documents from referring hospitals, elements of written communication were abstracted in a standardized fashion and included the presence of outside records, documentation of the medical course and care, and information received after the patient’s arrival. Comprehensive descriptive statistics summarized the information communicated.

Results: Over the two year period, 129 patients met inclusion criteria. 87.6% (n=113) of charts contained referring hospital documents. Substantial numbers of history and physicals (42.5% [n=48]), diagnoses (9.7% [n=11]), and reasons for transfer (18.6% [n=21]) were missing. 91 CT scans were performed; of which, final reads were absent for 76.9% (n=70). 45 ultrasounds and x-rays were performed; of which, final reads were missing for 80% (n=36). Services outside the ED were consulted at the referring hospital for 32.7% (n=37) of patients; consultants’ notes were absent in 89.1% (n=33). In 12.4% (n=14), referring facility paperwork arrived after the patient’s ED arrival time, and thus was not part of the original written communication provided.

Conclusion: Effective communication is an essential component of patient care. This study documents that information critical to continuity of care is often missing in the written communication provided during interhospital transfers. Establishing the current state of this communication affords a foundation for the standardization of provider communication during interhospital transfers of EGS patients.

 

93.13 Assessing Anastomotic Perfusion in Colorectal Surgery with Indocyanine Green Fluorescence Angiography

A. Dinallo1, W. Boyan1, B. Protyniak1, A. James1, R. Dressner1, M. Arvanitis1  1Monmouth Medical Center,Surgery,Long Branch, NEW JERSEY, USA

Introduction:  Major factors to prevent anastomotic leaks include adequate perfusion, tension free and minimal spillage.  Conventional techniques to assess viability of bowel perfusion such as palpating pulses and evaluating color and bleeding of cut edges are all critical techniques during colorectal surgery; however they are subjective. Like all medical practice, concrete objective data would be ideal while performing an anastomosis during colorectal surgery. The use of Indocyanine Green Fluorescence Angiography seeks to provide objective data when assessing tissue perfusion. 

Methods:  Between June 2013 and November 2015, 176 colorectal resections were retrospectively reviewed. The perfusion to the colon and ileum was clinically assessed, and then measured using SPY Elite Imaging System. The absolute value provided an objective number on a 0-256 gray scale, which represents differences between ICG fluorescence intensity and therefore perfusion. The lowest absolute value was used in data analysis as it represented the least perfused anastomotic portion.

Results:  There were 93 resections done for malignant disease and 83 resections performed for benign disease. There were a total of eleven operations that required additional proximal resections due to low ICG readings. Complications included two anastomotic leaks (1.1%) and three stenoses (1.7%). One anastomotic leak resulted in a mortality from sepsis. The mean ICG absolute values for all of the colon resections was greater than 51.  

Conclusion:  This study represents a 29-month experience at a single institution using the SPY technology in colorectal surgery. To date this the largest collection of data using SPY to objectively assess bowel perfusion in creating an anastomosis. The statistical significance of these values in relation to perfusion and anastomotic leaks has yet to be established in the literature. To determine these values randomized control trials are required. 

 

93.12 Evaluation of the Use of Preoperative Venous Thromboembolism (VTE) Prophylaxis in Surgical Oncology Patients

L. S. Anewenah1, A. Nadler1, K. Krauss1, R. Uzzo1, E. Sigurdson1, J. Farma1  1Fox Chase Cancer Center,Department Of Surgical Oncology,Philadelphia, PA, USA

Introduction:

The purpose of the study was to examine the administration and complications of pre-operative chemical VTE prophylaxis(pVTE) at an institutional level amongst complex surgical oncology patients to help inform policy creation.

Methods:
A retrospective study at a tertiary referral cancer center was performed. Data of all patients undergoing surgery in 2014 were analyzed for the use of preoperative chemical VTE prophylaxis.  We did not include analysis of postoperative VTE prophylaxis in this study.  Groups were subdivided by inpatient and outpatient status. Chi-square tests were performed.

Results:

Of the 4,954 procedures performed during 2014, 1,554 received chemical prophylaxis in the form of subcutaneous Heparin 5000 units prior to the start of the procedure. Overall administration rate in the institution was 31%. Inpatients had a significantly higher administration rate compared to outpatients (47% vs. 16%, OR 4.87, CI 4.26-5.57, p < 0.001).  By service, pVTE prophylaxis administration was observed in 53.1%, 40.2%, 27.5%, 20.4%, 16.3%, 13.6% and 4.9% for Urologic Oncology, General Surgical Oncology, Gynecological Oncology, Head and Neck Oncology, Breast Oncology, Plastic and Reconstructive Surgery, and Thoracic Oncology, respectively. Of the 27 surgical patients who developed postoperative VTE, 10 had received pVTE prophylaxis and 17 had not (OR 1.29, CI 0.59-2.82, p=0.524). Return to the operating room for bleeding was observed in 0.8% of all surgical patients who had received pVTE prophylaxis compared to 0.2% of patients who had not (OR 3.77, CI 1.48-9.60, p = 0.003). For inpatient surgical patients, however, 0.9% who had received pVTE prophylaxis returned to the operating room for bleeding whereas 0.4% patients without prophylaxis did (OR 2.45, CI 0.65-7.06, p = 0.087).   

Conclusion:

Given that less than a third of surgical patients received pVTE prophylaxis, further analysis of the data is needed to determine if other forms of VTE prophylaxis was used,  and if not, factors associated with no administration. Such analysis will help develop an institutional and potentially nationwide policy change and quality improvement efforts to address pVTE for complex surgical oncology patients. 

 

93.11 Can We Do That Here? Setting the Scope of Surgical Practice at a New Safety Net Community Hospital

S. K. Frencher2,6, A. Sharma7, S. Seresinghe5, S. M. O’Neill1,3  1University Of California – Los Angeles,Department Of Surgery,Los Angeles, CA, USA 2University Of California – Los Angeles,Department Of Urology,Los Angeles, CA, USA 3VA Greater Los Angeles Healthcare System,Los Angeles, CA, USA 4University Of California – San Diego,San Diego, CA, USA 5University Of California – Santa Barbara,Santa Barbara, CA, USA 6Martin Luther King, Jr. Community Hospital,Los Angeles, CA, USA 7University Of California – Los Angeles,Los Angeles, CA, USA

Introduction:
Setting the scope of surgical practice at a new hospital must address the competing objectives of patient safety, quality and reliability, and access to care. New hospitals, by definition, lack institutional knowledge and experience, and different hospitals will have differing internal capabilities, differing financial considerations, and differing community responsibilities. In particular, safety net community hospitals face a unique set of constraints, and fulfilling all of these objectives simultaneously is a challenge. Even in the most well-established hospital systems, surgical privileging, the mechanism by which scope of practice is effectively defined, remains an ongoing challenge. Initial adoption of our staff surgeons’ privileges from other hospitals caused mismatches in terms of support staff capability, equipment, and system readiness. This resulted in several instances with concerning implications for patient safety. Therefore, we present a case study in how we developed an approach to setting the scope of surgical practice at a newly-opened, non-trauma-designated safety net community hospital.

Methods:
At the outset, patient safety and quality of care were explicitly prioritized above having a broad scope of practice. Through interviews with staff, data was collected in regard to the appropriateness, surgeon expertise, and system readiness for all procedures listed on original privileging cards across 12 surgical specialties. We then began a process to review privileges for each specialty in person—first with affiliated surgeons, then with a larger group of all key clinical and administrative stakeholders in the spectrum of surgical care—Nursing and Allied Health Services, Anesthesia, Emergency Medicine, Hospital Medicine, and Operating Room management. For each procedure, four questions needed to be answered affirmatively and unanimously: Could a surgeon do this procedure here? Would a surgeon do this procedure here? Do we have, or could we reasonably acquire, the equipment needed for the procedure? Are all the perioperative services ready for this type of patient, and prepared to handle any likely complications? These meetings, often after robust discussions, yielded clear and unanimous decisions, and privileging forms were revised accordingly.

Results:
This process resulted in a significant (>40%) reduction in the number and complexity of procedures, from an initial list of more than 800. There was a focus on acute surgery, reflecting community needs. For some specialties more procedures were removed than remain, in particular Ophthalmology (>90% reduction) and Neurosurgery. The incidence of patient safety events due to inappropriate levels of care has been reduced; fewer than 50 different types of procedures are performed with regularity.

Conclusion:
Establishing the scope of surgical practice at a new safety net hospital is challenging and must strive for multiple objectives, but can be accomplished through collaborative, surgeon-led processes. 
 

93.10 A Sequential Implementation Pathway for Surgical Safety Checklist Introduction in Ambulatory Surgery Centers

J. Lagoo2,3,6, R. Singal3,6, E. George3,6, J. Durney3,6, S. Lipsitz3,6, B. Neville3,6, B. Neal3,6, D. Schaps6, M. Miller4, M. Cook5, W. Berry2,3,6, A. Haynes1,3,6  1Massachusetts General Hospital,General Surgery,Boston, MA, USA 2Brigham And Women’s Hospital,General Surgery,Boston, MA, USA 3Harvard T.H. Chan School Of Public Health,Boston, MA, USA 6Ariadne Labs,Boston, MA, USA 4Agency For Healthcare Research And Quality,Rockville, MARYLAND, USA 5American Hospital Association,Chicago, ILLINOIS, USA

Introduction: The World Health Organization Safe Surgery Checklist (SSC) has been shown to reduce morbidity and mortality with structured implementation in diverse settings worldwide. While published data has focused on hospitals, there is also interest in improving teamwork and communication through use of the SSC in ambulatory surgery centers (ASCs), where a high volume of procedures are performed. We hypothesize that ASCs must follow a sequential implementation pathway before sustainable use is achieved. Success in each step should predict success in the next, with higher baseline predicting greater likelihood of success in the program.

Methods: A national collaborative of stakeholders, supported by the Agency for Healthcare Research and Quality, aided in structured SSC implementation. Coaches facilitated implementation through a collection of baseline data, webinars, and one-on-one coaching for focused problem solving. A scoring system was created to evaluate stepwise completion of the SSC implementation program: baseline, preparation (initial roll-out), local ownership (individual site customization), expansion (institutional spread), and sustainability (continuous quality improvement). Partial correlation coefficients assessed the strength of the relationships between scores in our hypothesized implementation pathway, controlling for scores in prior steps on the pathway.

Results: Among the 180 ASCs with implementation data, the score ranges were: baseline (0.4, 11.3), preparation (0, 7), local ownership (0, 3), spread (0, 3), sustainability (0, 2), with higher scores meaning better performance on that step. Figure 1 displays all significant (p<0.05) partial correlations and shows that higher baseline score was positively correlated with preparation score (ρ=0.31, P<0.0001).  In turn, higher preparation scores were positively correlated with local ownership (ρ=0.43, P<0.0001) and spread (ρ=0.25, P=0.04008). Higher local ownership scores were positively correlated with spread (ρ=0.43, P<0.0001) and sustainability (ρ=0.25, P<0.0009). Finally, improved spread scores were positively correlated with sustainability (ρ=0.35, P<0.0001). 

Conclusion: Our data demonstrate that following a sequential implementation pathway including preparation, local ownership, spread in the facility, and focus on sustainability can lead to facility checklist adoption. Success in each step predicted success in the next and status of a facility at baseline predicted early success.

 

93.09 Are NSAIDs associated with postoperative complications in gastrointestinal surgery?

M. N. Mavros1, D. K. Kalaitzoglou2, E. N. Gatsouli2, K. P. Economopoulos2,3  1MedStar Washington Hospital Center,Surgery,Washington, DC, USA 2Society Of Junior Doctors,Surgery,Athens, ATTIKI, Greece 3Massachusetts General Hospital,Surgery,Boston, MA, USA

Introduction:  The perioperative use of non-steroid anti-inflammatory drugs (NSAIDs) has increased over the past decades in an attempt to limit the use of opioids and associated complications. Recent evidence however suggests that NSAIDs may be associated with higher incidence of postoperative complications.

Methods:  A systematic review and meta-analysis of the existing literature was performed using the PRISMA guidelines. Both randomized and non-randomized studies were included. Sensitivity analyses were performed based on study design and class of NSAID [non-selective vs. selective cyclooxygenase 2 (COX2) inhibitor]. Calculation of pooled odds ratios (OR) and 95% confidence intervals (CI) was performed using the DerSimonian-Laird random-effects model.

Results: A total of 498 studies were identified, of which 16 (24,126 patients) were included in the meta-analysis. Six studies (502 patients) were randomized controlled trials (RCTs) and the remaining were retrospective in design. In 13 studies (23,340 patients) non-selective NSAIDs were administered, while COX2-selective NSAIDs were used in 5 studies (1,731 patients; both classes were used in 2 studies). In 14 of 16 studies, the patients underwent colorectal surgery. About 5.1% of patients (1229/24126) developed anastomotic leak postoperatively (3.8% in RCTs); incidence of leak was significantly associated with perioperative use of NSAIDs (OR=1.83; 95%CI: 1.39–2.43, p<0.001). This effect remained significant at sensitivity analysis by study design (RCTs only: OR 3.38, 95%CI: 1.23–9.28, p= 0.02) and the same trend was observed when studies were pooled by NSAID class (non-selective: OR=1.52, 95%CI: 1.21–1.91, p<0.001; COX2-selective: OR=2.48, 95%CI: 0.999–6.15, p=0.05). Based on results from retrospective studies, there was no difference in the incidence of surgical site infections (OR=0.95, 95%CI: 0.53–1.65, p=0.85); however there was a trend towards lower mortality in patients getting NSAIDs (OR=0.58, 95%CI: 0.34–1.01, p=0.05). Sensitivity analysis attributed this trend to the subgroup of patients receiving non-selective NSAIDs (OR=0.42, 95%CI: 0.32–0.55, p<0.001).

Conclusion: Perioperative use of NSAIDs may have beneficial effects in terms of pain management and length of hospital stay, however based on our analysis this comes at the cost of increased rate of anastomotic leak. Limited data based on retrospective studies suggesting lower mortality in patients receiving non-selective NSAIDs need to be reproduced in randomized studies. Further research may focus on the risk-benefit and decision-making analysis to balance the overall (beneficial and detrimental) perioperative effects of NSAIDs in gastrointestinal surgery.

 

93.08 The Cost of Increasing Adherence to VTE Prophylaxis Guidelines: Our QI Experience

S. J. Layne2, E. A. Bailey1, R. R. Kelz1, C. M. Vollmer1  1University Of Pennsylvania,Center For Surgery And Health Economics, Department Of Surgery,Philadelphia, PA, USA 2Perelman School Of Medicine At The University Of Pennsylvania,Philadelphia, PA, USA

Introduction: National guidelines recommend that physicians prescribe 4 weeks of extended venous thromboembolism (VTE) prophylaxis to high-risk patients who have undergone major abdominal or pelvic surgery for cancer. Despite growing evidence in support of these guidelines, recent studies continue to find low rates of adherence. While factors contributing to low adherence have not been directly evaluated, many barriers have been suggested including high cost, inadequate insurance coverage, and physician perceptions and prescribing patterns. This study evaluates the results of a local quality improvement (QI) initiative to increase appropriate use of extended VTE prophylaxis and the subsequent out of pocket (OOP) cost to patients.

 

Methods: We performed a retrospective cohort study of all high-risk patients (Caprini score >=5) who underwent surgery for cancer on our hepatobiliary surgery service between February and June 2016. This period encompassed 2 months before and 3 months after initiation of a formal extended prophylaxis protocol (EPP) in April 2016. We used the Wilcoxon test to compare the percentage of eligible patients who were appropriately prescribed extended prophylaxis at discharge before and after this intervention. The incidence of DVT, PE and bleeding events were compared before and after initiation of the EPP. Descriptive statistics were performed to assess the OOP cost to patients.

 

Results: 63 high-risk patients underwent abdominal surgery for cancer during the study period. 52 patients remained in the final study cohort. Prior to the QI intervention, 3 out of 20 eligible patients (15.0%) received extended prophylaxis at discharge. In the post-intervention period, 78% of patients (25/32) were prescribed extended prophylaxis representing a significant increase in adherence to the guidelines (p<0.001) (Figure 1). In both pre- and post-intervention groups, no DVT, PE, or bleeding events occurred after discharge. The median OOP cost required for patients to fill their lovenox prescription was $20 although reported costs ranged from $0-$565 (IQR [$10,$101]. Only 1 patient in the post-intervention period refused extended prophylaxis due to prohibitively high OOP cost.

 

Conclusion: Adherence to extended VTE prophylaxis guidelines improved from 15% to 78% during the study. We were unable to show an overall reduction in VTE events due to our small sample size. Out of pocket cost to the patient for extended prophylaxis was relatively low and did not pose a significant patient-driven barrier.

93.07 Association between Hospital Safety Attitudes and Failure to Rescue Rates

S. T. Ward1, D. A. Campbell1, C. Friese2, J. B. Dimick1, A. A. Ghaferi1  1University Of Michigan,Department Of Surgery,Ann Arbor, MI, USA 2University Of Michigan,School Of Nursing,Ann Arbor, MI, USA

Introduction: Failure to rescue (FTR) is associated with multiple hospital macro-system factors such as hospital technology, nurse staffing and teaching status.  However, these factors do not account for the majority of variation in FTR. Micro-system factors, including safety attitudes, have been proposed as a potential contributor to FTR. In this study, we investigate safety attitudes in hospitals with varying FTR rates.

Methods: Using prospectively collected data from the Michigan Surgical Quality Collaborative (MSQC), we identified 44,567 patients between 2008-2012 who underwent major general or vascular surgery procedures. Hospitals were divided into tertiles based on risk adjusted FTR rates. We then administered a Safety Attitude Questionnaire (SAQ) to nurses and physicians across surgical units in the state of Michigan. We examined the association between FTR rates and SAQ scores in two major domains— Teamwork Climate and Safety Climate.

Results: FTR rates across the tertiles were 8.9%, 16.5% and 19.9% respectively, p < 0.001.  There were no significant differences in perceived Teamwork or Safety Climate between low and high FTR hospitals. The SAQ Teamwork Climate scores for all providers combined were 76, 78, and 76 from the lowest to highest FTR tertiles. The Safety Climate scores were 75, 77, and 75 from the lowest to highest FTR tertiles. When stratified by professional group, physicians tended to rate these two domains higher than nurses within the same FTR tertile.    

Conclusion:  There was no association between safety attitudes and FTR rates between hospitals. The SAQ may only represent a small snapshot of culture within a surgical unit. However, timely and effective rescue requires interdisciplinary and cross-unit responses to crisis. Therefore, developing an accurate hospital-wide barometer of safety attitudes is needed.

93.06 The “Quality Minute:” A Brief, Structured Technique for QI Education During the M&M Conference

R. L. Hoffman1, E. Bailey1, J. B. Morris1, R. R. Kelz1  1Hospital Of The University Of Pennsylvania,Philadelphia, PA, USA

Introduction: The integration of quality improvement and patient safety (QIPS) knowledge within surgical educational has been limited by competing priorities, generational attitudes, and knowledge intimidation. The morbidity and mortality (M&M) conference is a shared educational space already structured around QIPS, and therefore, may lend itself to the addition of an educational moment to benefit all levels of learners. The aim of this study was to evaluate the incorporation of a brief, structured QI presentation during the M&M conference on learner satisfaction and QIPS knowledge.

Methods: Every 8 weeks over the course of one academic year, six 5-7 minute presentations, each on a different QIPS topic pertinent to the institution, were included as part of an “interesting case” rotation during M&M at one large academic training program. The “quality minute” included presentations on outcome measures (eg.,catheter-associated urinary tract infections), processes of care (eg.,enhanced recovery protocols), and measurement concepts (eg., O/E ratio). Each presentation included education of a fundamental QIPS skill or method (e.g., DMAIC) highlighting the application at the institution level. At the conclusion of the year, all attendees were invited to participate in an 8 item survey to assess the impact of the “QI minute” on their understanding of the language and concepts of QI.

Results:There were an average of 73 attendees at each conference; 35 faculty (47.9%), 28 residents (38.4%), 7 (9.6%) advanced practice providers (APP) and 3 (4.1%) fellows. The overall response rate was 62.1% (45); 65.7% (23) for faculty, 64.3% (18) for residents, 42.9% (3) for APP, and 1 identified as “other.” Overall, 82.2% (37) of respondents agreed that the “quality minute” was a positive addition to the M&M conference, 77.8% (35) agreed that they learned valuable information on QIPS methodology, 73.3% (33) agreed that the dialogue around QIPS was increased, and 64.4% (29) had a better understanding of the data behind quality reporting. There were no significant differences in level of agreement between residents and faculty. Qualitative assessment of free text items (13 comments) on the best part of the QI minute revealed 4 main themes: Increased dialogue (5), relevance to practice (5), time (4), clarity of presentation (2). Regarding areas for improvement, 15 comments addressed 5 themes: topics (6), desire for increased frequency (4), desire for increased divisional participation (2) and time (1).

Conclusion:The addition of a short, structured QI presentation during M&M conference provided an opportunity to educate faculty, trainees and APP in QIPS and provided a shared forum for increased dialogue that was positively received. The integration of the QIPS minute into the M&M conference enhanced the overall QIPS engagement within the department.
 

93.05 Laparoscopic Cholecystectomy Conversion: Risk Factors and Trends at a Single Institution

J. N. Byrd1, I. Nassour3, H. Zhu4, D. Xiang1, S. Luk2, J. Minei2, M. Choti1  2University Of Texas Southwestern Medical Center,Division Of Burn/Trauma/Critical Care, Department Of Surgery,Dallas, TX, USA 3University Of Texas Southwestern Medical Center,Department Of Surgery,Dallas, TX, USA 4University Of Texas Southwestern Medical Center,Department Of Clinical Science,Dallas, TX, USA 1University Of Texas Southwestern Medical Center,Dallas, TX, USA

Introduction:
Rates of conversion from laparoscopic to open cholecystectomy in the U.S. have been reported to be 5 to 10%. Conversion is an intraoperative decision made in the interest of patient safety. There is no consensus about the predictors of conversion for laparoscopic cholecystectomy. This study aims to identify preoperative factors that are predictive of conversion at a large, safety-net hospital.

Methods:
The data for all patients who underwent laparoscopic and converted cholecystectomies from 2007 to 2015 were retrospectively reviewed in the electronic medical records of a public, teaching hospital. We excluded cholecystectomies performed as part of a cancer operation or secondary to trauma. Baseline demographic and clinical factors were summarized by medians and interquartile ranges for continuous variables and by counts and percentages for discrete variables. Univariate and multivariate logistic regression were used to identify the factors that are significantly associated with conversion.   

Results:
We identified 9,008 patients: 84.0% were female, 77.8% were Hispanic, and 75.2% were uninsured, with a median age of 37 (29-47) years. 10.5% of patients were ASA 3 or 4 with comorbidities including hypertension in 19.8% of cases, diabetes mellitus in 10.2% of cases, and renal failure in 0.5% of cases.  The majority (81.8%) of cases were performed between 7 a.m. and 3 p.m. Ambulatory cases accounted for 31.1% of patients. There were 451 converted cholecystectomies across all case types – a conversion rate of 5.0%. On multivariable analysis, predictors of conversion were male gender (odds ratio (OR)=2.68; 95% confidence interval (CI): 2.09-3.43), increased age (OR=1.02; 95% CI: 1.02-1.03), diabetes mellitus (OR=1.42; 95% CI: 1.04-1.95), increased BMI (OR=1.018; 95% CI: 1.001-1.03), increased WBC count (OR=1.034; 95% CI: 1.01-1.06), and increased alkaline phosphatase (OR=1.002; 95% CI: 1.001-1.003). Ambulatory cases were associated with a decreased conversion rate (3.1%) compared to inpatient cases (OR=0.458, 95% CI: 0.4-0.9). Patients seen in 2007-2010 had a higher conversion rate than those in 2011-2015 (6% vs. 4.3%, OR=1.49, 95% CI: 1.18-1.88). There was no difference in conversion rate by surgery start time, with a rate of 5.2% for 7370 cases from 7 a.m. to 3 p.m. and a rate of 5.7% for 1638 cases from 3:01 p.m. to 6:59 a.m. (p=0.45). 

Conclusion:
Male gender, age, BMI, high ASA status, diabetes mellitus, WBC, alkaline phosphatase, and non-ambulatory case status were independent predictors of conversion. Conversion rate did not vary by time of surgery. Application of these pre-operative patient factors as a predictive model for increased risk of conversion can facilitate improved planning and management.
 

93.04 Opioid Prescribing and Education Following Uncomplicated Outpatient Laparoscopic Cholecystectomy

R. Howard1, J. Lee1, C. Brummett1, J. Waljee1, M. Englesbe1  1University Of Michigan,Ann Arbor, MI, USA

Introduction:
Mortality related to prescription opioid medications has quadrupled since 1999. Not only are the patients who receive the prescription at risk, with 5-20% remaining dependent for months following surgical procedures, but these prescriptions introduce excess opioids into the community, leading to increasing diversion. This makes practices in postoperative opioid prescription and patient counseling, for which there are no widely accepted guidelines, a critical element in managing the opioid epidemic.

Methods:
A retrospective chart review was conducted of all patients who underwent uncomplicated outpatient laparoscopic cholecystectomy between January 2015 – July 2016 at a large academic medical center. Initial postoperative opioid prescriptions were examined for prescribing provider type and amount prescribed in oral morphine equivalents (OMEs). Written discharge instructions for each patient were also reviewed to identify those that contained specific instructions regarding typical use of opioids, risks of addiction, and use of non-opioid analgesics. Descriptive analysis was used to characterize opioid prescriptions and written discharge instructions.

Results:
A total of 123 patients underwent outpatient laparoscopic cholecystectomy during the study period. Mean age was 45±14 years and 78% of patients were female. All patients received a prescription for opioids and 92% were prescribed by surgical residents. Average total OME prescribed was 247±93 mg (approximately equivalent to 50 tablets of hydrocodone/acetaminophen 5/325) with a range of 60-600 mg (equivalent to 12-120 tablets of the same). Medications prescribed included hydrocodone/acetaminophen 5/325 (80%), oxycodone 5 mg (13%), oxycodone/acetaminophen 5/325 (5%), and tramadol (2%). Written discharge instructions also varied widely. Only 40% of patients received instructions regarding use of ibuprofen or acetaminophen, with 21% of instructions specifically recommending that patients start with these first, and only 7% stating that many patients find that opioids are not necessary at all. The risks of addiction were specifically discussed for only 33% of patients. No patients received written instructions regarding the risks of leftover medication or safe disposal.

Conclusion:
Postoperative opioid prescriptions and written patient instructions vary widely following a routine outpatient surgical procedure. Furthermore, patients are infrequently informed about non-opioid options for pain control and the risks of addiction. Given that postoperative opioid prescription plays a key role in patient safety and drug diversion, future efforts should be aimed at safe prescribing practices and providing patients with appropriate information.
 

93.03 Risk factors of postoperative pneumonia in patients who underwent transthoracic esophagectomy.

M. Hayashi1, H. Takeuchi1, F. Kazumasa1, R. Nakamura1, K. Suda1, H. Kawakubo1, N. Wada1, Y. Kitagawa1  1Keio University School Of Medicine,Department Of Surgery,Shinjyuku, TOKYO, Japan

Introduction:
It is reported that transthoracic esophagectomy for esophageal cancer is associated with higher risk than other gastrointestinal surgeries and its postoperative complication rate is up to about 45%. Among the complications, respiratory complication is most common and it may cause perioperative death. In this study, risk factors of postoperative pneumonia (? Clavien-Dindo’s Classification II ) was examined.

Methods:
From January 2012 to April 2016, we examined 176 patients who underwent transthoracic esophagectomy. From postoperative period to discharge, we divided the cases into two groups : postoperative pneumonia’s group and no postoperative pneumonia’s group, and risk factors of postoperative pneumonia were examined. Postoperative pneumonia was diagnosed by detecting fever, high inflammation, and x-ray or computed tomography (CT) showing infiltrative shadow retrospectively. Age at the surgery, preoperative forced expiratory volume in 1second (FEV 1.0), % vital capacity (%VC), preoperative body mass index (BMI), and preoperative endoscopic treatment were examined whether they are risk factors of postoperative pneumonia or not. Referring to the average of postoperative pneumonia’s group FEV 1.0 : 2.56 L, we defined 2.40 L as cutoff value of preoperative FEV 1.0. Using the number, we divided FEV1.0 higher group and lower group.

Results:
Among 176 cases, male was 144 (81.8 %) and female was 32 (18.2 %). The mean age at the operation was 64.2. Preoperative mean FEV1.0 was 2.71 L, and preoperative mean %VC was 102.2 %. Postoperative pneumonia was 42 (23.9 %). In postoperative pneumonia group’s mean FEV1.0 was 2.56 L and no postoperative pneumonia group’s mean FEV1.0 was 2.76 L. We could not recognize statistically-significant difference among age at the surgery, preoperative %VC, preoperative BMI, or preoperative endoscopic treatment. About preoperative FEV1.0, p value was 0.04 and odds ratio was 0.49. It suggests that less than 2.40 L FEV1.0 tends to have postoperative pneumonia. In cases which FEV1.0 was less than 2.40, postoperative pneumonia was 19 (11.0 %).

Conclusion:

It is thought that preoperative FEV1.0 was risk factor of postoperative pneumonia in patients who underwent transthoracic esophagectomy..From this study, we should consider to use stronger preoperative respiratory training

in cases which preoperative FEV1.0 is less than 2.40 L.

93.02 Teamwork in the Pediatric Operating Room – A New Target for Improving Patient Safety

C. K. Shoraka1,2,3, J. Wang1,2,3, J. E. Abraham1,2,3, K. M. Masada1,2,3, A. N. Minzenmayer1,2,3, K. T. Anderson1,2,3, K. Tsao1,2,3, K. P. Lally1,2,3, A. L. Kawaguchi1,2,3  1The University Of Texas Health Science Center At Houston,McGovern Medical School,Houston, TX, USA 2Children’s Memorial Hermann Hospital,Pediatric Surgery,Houston, TX, USA 3Center For Surgical Trials And Evidence-based Practices (C-STEP),Houston, TX, USA

Introduction: Lapses in communication, cooperation, leadership, situational awareness, and other teamwork behaviors may result in avoidable patient harm. Thus far, teamwork in the operating room has been inadequately studied.  We evaluate teamwork behaviors in the pediatric operating room in order to identify areas for targeted improvement.

Methods: During 2015-2016, two 8-week observational study periods were conducted at a tertiary children’s teaching hospital with convenience sampling of elective pediatric surgery operations. Teamwork scores were assigned by trained observers using the Observational Teamwork Assessment for Surgery (OTAS) scale. The surgical, anesthetic, nursing, and scrub teams received a scaled composite score for each behavior – communication, coordination, cooperation/back-up behavior, leadership, and situational awareness – in the preoperative, intraoperative and postoperative phase. Descriptive statistics were used to assess variation in observed team behaviors. A p-value of < 0.05 was considered significant.

Results: A total of 496 cases were observed during 2015-2016. Across all teams, operative periods, and behaviors the mean OTAS score was 3.61 ± 0.74. Overall, surgical teams had the highest mean (± standard deviation) teamwork score, followed by nursing, anesthesia, and scrub teams, respectively (3.69 ± 0.81, 3.66 ± 0.73, 3.59 ± 0.71, and 3.49 ± 0.68; P < 0.001). Surgical teams exhibited the best communication (3.86 ± 0.88) and leadership (3.65 ± 0.83) with the poorest overall cooperation/back-up behavior (3.57 ± 0.76) (P < 0.001); nursing teams had the highest scores for cooperation/back-up behavior (3.83 ± 0.75) (P<0.001). Scrub technicians scored the lowest of all teams in leadership behavior (3.22 ± 0.46) (P<0.001). Nursing (3.84 ± 0.73, 3.61 ± 0.70) and anesthetic (3.78 ± 0.75, 3.51 ± 0.66) teams had the highest relative scores both pre-and postoperatively. Surgical teams the highest scores intraoperatively (3.95 ± 0.84) (P < 0.001).

Conclusion: This study revealed numerous areas for teamwork improvement in the pediatric surgical operating room – leadership roles for technicians, cooperation for surgeons, and intraoperative team involvement for nursing and anesthesia. Our patient safety efforts will focus on targeted teamwork improvements as well as correlation of these behaviors with patient outcomes.

 

93.01 Daily Enoxaparin Provides Inadequate VTE Prophylaxis For Most VATS Patients Based On Anti-Xa Levels

C. J. Pannucci1, K. I. Fleming1, L. Moulton2, A. Prazak3, T. K. Varghese2  1University Of Utah,Division Of Plastic Surgery,Salt Lake City, UTAH, USA 2University Of Utah,Division Of Cardiothoracic Surgery,Salt Lake City, UTAH, USA 3University Of Utah,Department Of Pharmacy,Salt Lake City, UTAH, USA

Introduction:

Thoracic surgery patients, particularly those with malignancy, are at elevated risk for perioperative venous thromboembolism (VTE).  Enoxaparin prophylaxis prevents VTE amongst surgical patients.  However, emerging literature demonstrates that enoxaparin is not a “one size fits all” intervention, and inadequate enoxaparin dosing has been associated with downstream VTE events in other surgical subspecialties.  We examined the pharmacodynamics of enoxaparin 40mg per day in VATS patients with an emphasis on 1) dose adequacy, measured by peak and trough anti-Factor Xa (aFXa) levels and 2) the association between gross weight and peak aFXa level.

Methods:

We prospectively enrolled patients after VATS procedures into this ongoing clinical trial (NCT02704052).  All patients received enoxaparin prophylaxis at 40mg once per day, initiated at 12-18 hours after their surgical procedure.  Steady-state peak and trough aFXa levels, which mark enoxaparin effectiveness and safety, were drawn.  Goal peak and trough aFXa levels were 0.3-0.5 IU/mL and 0.1-0.2 IU/mL, respectively.  Patients with out of range peak aFXa levels had real time enoxaparin dose adjustment based on a written protocol, followed by repeat aFXa levels.  Stratified analyses examined variation in peak aFXa by patient’s gross weight.

Results:

To date, 21 patients who received enoxaparin 40mg once daily after VATS surgery have been enrolled.  28.6% of patients had initial in range peak aFXa levels.  19.0% of patients had any detectable aFXa activity at 12 hours.  Real time enoxaparin dose adjustment was performed based on peak aFXa levels, and 100% of patients in whom repeat labs were drawn had in-range levels.  Gross weight was associated with peak steady state aFXa level in patients who received fixed dose prophylaxis (Figure 1).  Patients with gross weight over 150 pounds were significantly more likely to have inadequate aFXa levels when compared to patients ≤150 pounds (86.7% vs. 33.3%, p=0.031). 

Conclusion:

Enoxaparin 40mg once daily provides adequate prophylaxis for a minority of patients (28.6%) after VATS surgery. 19% of patients had any detectable aFXa activity at 12 hours.  Thus, for a medication administered daily, four out of five patients receive chemoprophylaxis for less than 12 hours per day.  Patients with gross weight >150 pounds were significantly more likely to have inadequate aFXa levels in response to fixed dosing.  These preliminary findings support an individualized and possibly weight based approach to post-VATS chemoprophylaxis. Further research from this ongoing study will 1) correlate aFXa levels with downstream VTE and bleeding events and 2) examine additional patient-level predictors of enoxaparin metabolism after VATS.

92.20 Early Outcomes of Fluorescence Angiography in the Setting of Endorectal Mucosa Advancement Flaps.

A. Okonkwo1, J. Turner1, A. Chase1, C. E. Clark1  1Morehouse School Of Medicine,Division Of Colon And Rectal Surgery/Department Of Surgery,Atlanta, GEORGIA, USA

Introduction: Fistulo-in-ano has a reported incidence of 31-34%. Non-cutting options for fistula repair are seton placement, endorectal or dermal advancement flaps, fibrin sealant, anal fistula plug, and ligation of the intersphincteric fistula tract (LIFT).  Endorectal advancement flap (ERAF) procedures are commonly performed in patients in whom traditional cutting procedures are relatively contraindicated such as high transphincteric fistulas, low transsphincteric fistulas in women and fistula associated with Crohn’s disease. Despite having a reported success rate as high as 75-98%, ERAF is not without complications including flap breakdown, recurrence and fecal incontinence. Traditionally, maintaining a broad base to maintain blood supply has been advocated to reduce flap failure. Here, we report our early experience and outcomes of adult patients who underwent ERAF for complex fistulo-in-ano with the use of intraoperative fluorescence angiography (FA) to reduce complications related to flap ischemia. 

Methods: We retrospectively reviewed a prospectively maintained dataset of patients with an age range of 18 to 99 at a single urban teaching hospital who underwent ERAF for complex fistulo-in-ano between July 2014 and June 2016 by board certified Colorectal Surgeons. All procedures that utilized FA were selected for review including 30 and 60 day outcomes. Patients without documented follow up were excluded. 

Results:Seven cases were identified with average age and BMI of 37.9 and 25.9, respectively. There were 6 males and 1 female. There were 85.7% of patients who had prior surgery for fistulo-in-ano. No recurrences or complications of any type were noted at 30 and 60 day follow-up. Five of the seven patients (71.4%) required revision of the flap based on intraoperative FA prior to flap fixation.

Conclusion:FA is safe and offers real-time assessment of flap profusion prior to fixation in fistula repair. The rate of flap ischemia may be under estimated and thus intraoperative FA should be considered in the surgical armamentarium to further improve outcomes in ERAF.

 

92.19 The Optical Trocar Access in Laparoscopic Gastrointestinal Surgery

C. Tanaka1, M. Fujiwara1, M. Kanda1, M. Hayashi1, D. Kobayashi1, S. Yamada1, H. Sugimoto1, T. Fujii1, Y. Kodera1  1Nagoya University Graduate School Of Medicine,Dept. Of Gastroenterological?Surgery,Nagoya, AICHI, Japan

Introduction: ~The optical trocar access is one of techniques for the first trocar placement in laparoscopic surgery. By the optical trocar access, each tissue layer can be visualized prior to penetration, leading to prevention of organ injury, and air leaks at the site of trocars can be minimized even in obese patients. The aim of this study is to report the comparison of the required time for a trocar insertion between the optical trocar access and open group in patients who underwent laparoscopic gastrointestinal surgery.

Methods: ~We reviewed our prospectively collected database and identified 384 patients who underwent the laparoscopic gastrointestinal surgery for whom the initial trocar was inserted nearby the umbilicus either by the optical trocar access or by the open method. Prior to comparison between the two methods, the propensity score matching was used to adjust for essential variables between the optical trocar access and open groups. After matching, we compared the influences of age, sex, BMI, comorbidity, history of abdominal surgery, type of diseases and surgeon’s experience of the optical trocar access on required time for an initial trocar insertion. BMI was categorized into not obesity (<25 kg/m2) or obesity (≥ 25 kg/m2).

Results:~Patients categorized either as optical trocar access or open group were matched one-to-one by the use of propensity score matching and 137 pairs of patients were generated. The required time for a trocar insertion was significantly shorter in the optical trocar access group in comparison with that of the open group (36.6 vs 209.8 seconds, respectively, P<0.01). The prolonged time for an initial trocar insertion of optical trocar access was significantly associated with younger age of the patient and surgeon’s experience of 30 cases or fewer in the univariable analysis. The multivariable analysis identified the small experience of the surgeon as the only independent risk factor for prolonged time for an initial trocar insertion (OR 3.45, 95% CI 1.49 – 8.33, P <0.01; Table 2). Notably, BMI and history of abdominal surgery did not significantly affect the required time for a trocar insertion in the optical trocar access group. On the other hand, the prolonged time for an initial trocar insertion of open group was significantly associated with body mass index (OR 3.22, 95% CI 1.22 – 8.90, P = 0.02) and history of abdominal surgery (OR 2.96, 95% CI 1.27 – 7.12, P = 0.01).

Conclusion:~This study indicated that optical trocar access may be recommended for insertion of initial trocar in laparoscopic gastrointestinal surgery.

 

92.18 Laparoscopic vs Robotic Transversus Abdominus Release Learning Curve: Is There a Difference?

A. S. Weltz1, N. Wu1, U. Sibia1, J. Chamu1, H. R. Zahiri1, I. Belyansky1  1Anne Arundel Medical Center,Minimally Invasive Surgery,Annapolis, MD, USA

Introduction:

We previously described a novel approach to transversus abdominus release (TAR) via laparoscopic technique.  Use of robotic platform to address TAR has also been previously reported.  Considering the complexity of anatomy and difficult technical aspects, both of these approaches are thought to be associated with a steep learning curve.  We evaluate a single surgeon’s operative outcomes and early learning curve with laparoscopic and robotic TARs.

Methods:

Review of prospectively collected data for a single surgeon was performed for a consecutive series of thirty-two patients that underwent laparoscopic TAR (n=24) and robotic TAR (n=10) from August 2015- August 2016. A board-certified fellowship trained MIS surgeon, completed 40+ hours of simulation training on the da Vinci Surgical System (Intuitive Surgical Inc, Sunnyvale CA) and additional cadaveric training prior to the start his robotic procedures. The learning curve was examined by averaging operating room (OR) times in intervals of 5 procedures.

Results:

Thirty-two patients (22 Lap TAR vs. 10 rTAR) with mean age (55.3 vs. 60.2 years, p=0.393), BMI (31.7 vs. 30.4 kg/m2, p=0.589) and ASA (2.4 vs. 2.4, p=0.930) were studied.  Estimated blood loss (60.2 vs. 63.5 ml, p=0.758) and length of stay (2.3 vs 1.9 days, p=0.647) were equivalent. In laparoscopic TAR, operating room times (ORT) decreased from an average of 335.0 mins for the first five cases to 249.4 mins for the 6-10th cases (p=0.008).  In robotic TAR cases ORT decrease from average 323.2 mins for first 5 cases to 220.4 mins for the 6th-10th cases (p=0.108).  There was no significant difference in ORT when comparing laparoscopic vs robotic 6th-10th cases, 249.4 vs 220.4 mins (p=0.49) respectively.  Significant decrease in ORT for laparoscopy was seen comparing 1st-5th vs 15th-20th cases, 335.0 vs 253.4 mins respectively (p=0.006), but no significant difference when comparing 6th-10th vs 15th-20th cases implying the saturation of the learning curve was achieved between 6th and 10th cases.  Wound and non-wound related complications were equivalent at a mean follow up of 6 months.

Conclusion:

Our review of laparoscopic and robotic TAR experience revealed no difference in the learning curves when comparing laparoscopy to robotics in the hands of an MIS expert surgeon. Operative time revealed a significant downward ORT trend with an increased number of cases in both groups, with low morbidity.

92.17 Outcomes of Inguinal Herniorrhaphy with Concomitant Robotic Prostatectomy

M. H. Zeb1, N. D. Naik1, T. K. Pandian1, A. Jyot1, H. Y. Saleem1, E. F. Abbott1, M. Monali1, E. H. Buckarma1, D. R. Farley1  1Mayo Clinic,Dept Of Surgery,Rochester, MN, USA

Introduction:
Robotically assisted radical prostatectomy (RARP) with concomitant robotic inguinal hernia repair is an alternative to performing either procedure in separate settings. The safety and outcome of performing these procedures concomitantly is not well documented. We aimed to assess our experience and identify risk of recurrent hernias and other postoperative complications specifically surgical 

Methods:
We retrospectively analyzed all adult patients (age >18 years) who underwent RARP with concurrent robotic inguinal hernia repair from 2008 to 2016 at our institution. Patient characteristics and operative details were extracted from the medical records. Descriptive statistics were calculated for all demographic and clinical variables and were reported as mean ± standard deviation (SD), median with interquartile ranges (IQR) or as a proportion.

Results:

65 male patients were identified who underwent the concurrent procedures [mean age=63 (SD ±6), range=50-75 years, mean BMI=27.9 kg/m2]. Median follow-up was 357 days (IQR 94-1560). Mean ASA score was 2. Mean estimated blood loss was 216 mL (SD±162). Twenty two (33%) patients underwent bilateral repair and 43 (67%) patients underwent unilateral repair. No patient had a surgical site infection. Hematomas due to arterial bleeding in the obturator fossa from lymph node dissection required surgical evacuation in two patients. One patient developed a seroma in the inguinal region. In addition, two patients developed hematuria and one patient developed a transient bowel obstruction. A total of four patients developed post-procedure hernias, two of which were port site hernias within 1 year of the procedure while two were ipsilateral recurrent inguinal hernias.

Conclusion:

Concomitant robotic hernia repair with RARP appears to be safe and effective with a low incidence of the port site and recurrent hernias. However, more studies need to be done with a longer follow-up to assess the long term risk of developing these complications.

 

92.16 Lack of Association Between Lymph Node Metastasis and Nodule Size in Differentiated Thyroid Cancer

D. Bu Ali1, K. Mohsin1, D. Monlezun1, E. Kandil1  1Tulane University School Of Medicine,Surgery,New Orleans, LA, USA

Introduction:

Several studies have reported the association between large thyroid nodules and the increased incidence of lymph node metastasis in differentiated thyroid cancer. We aim to investigate the use of thyroid nodule size  in predicting lymph node (LN) metastasis in differentiated thyroid cancer (DTC). 

 

Methods:

This is a retrospective review of all patients who underwent thyroidectomy for (DTC)  by a single surgeon in an academic institution over 5 years. Clinicodemographic data, histopathological data and preoperative ultrasound features including nodule size and presence of internal vascularity or calcification were analyzed. Patients were divided into two groups based on the presence of positive LN.

 

Results:

A total of 139 patients were included, 28 (20.9%) had positive LN metastasis and 106 (79.1%) were non metastatic. There was no significant difference in nodule size on ultrasound between the two groups. The mean nodule size for the group with metastatic LN was 2.7 ± 1.5 cm and 2.5 ± 1.4 cm, for the non-metastatic group (p=0.48).  In addition, there was no association between larger nodule size and presence of positive LN metastasis, even in the combination with other ultrasound features such as calcification and internal vascularity (p>0.05).  However, there was a significant association of positive LN metastasis with the presence of positive BRAF mutation (OR: 14.32, p<0.001, Sens.= 87.5%, Spec. = 67.2%, PPV= 48.8%, NPV= 93.8%, Acc.= 72.5%)

 

Conclusion:

Larger thyroid nodule size on ultrasound is not associated with increased risk of LN metastasis in DTC. However, the presence of positive BRAF mutation was predictive of increased risk of presence of metastatic LN. Further future larger studies are required to validate these findings.  

 

 

92.15 Laparoscopic vs. Open Inguinal Hernia Repair: A Single-Center Analysis of Long Term Quality of Life

N. J. Mier1, M. C. Helm1, Z. Helmen1, M. E. Bosler1, A. Nielsen1, A. Kastenmeier1, J. C. Gould1, M. I. Goldblatt1  1Medical College Of Wisconsin,Milwaukee, WI, USA

Introduction:  Inguinal hernias are among the most common surgical procedures done in the world.  For decades, open hernia repair was the only option. However since the 1990’s, laparoscopic repairs have given patients another surgical option.  Recent studies suggest that open approach to hernia repair is associated with a greater incidence of chronic pain and patient dissatisfaction.  We evaluated quality of life (QOL) in patients who underwent open or laparoscopic inguinal hernia repairs at Froedtert and the Medical College of Wisconsin.  We hypothesized that patients undergoing laparoscopic inguinal hernia repairs would have improved QOL scores at six months and one year.

Methods:  This study was a retrospective analysis of adult patients who underwent inguinal hernia repair at the Condon Hernia Institute at Froedtert and the Medical College of Wisconsin between September 2012 and July 2016. All patients were administered Short Form-12 (SF-12) surveys at standard intervals to assess patient quality of life.  Physical and Mental Composite Scores (PCS and MCS) scores were calculated pre-operatively and post-operatively up to one year. Statistical analysis was performed using a T-test and Mann-Whitney U test for continuous variables and Chi-square test for categorical variables. A statistical significance was defined as p < 0.05.

Results: See Table

Conclusion

When comparing laparoscopic versus open inguinal hernia repairs at Froedtert and the Medical College of Wisconsin, we found that:

1) Patients who underwent open repair were older and more likely to have hypertension.

2) Patients with a history of abdominal surgery were more likely to undergo an open repair.

3) There was no difference in long-term QOL scores between laparoscopic and open repair as measured by the mental composite scores and physical composite score