85.19 Male Breast Cancer: A Review of One Tertiary Center Hospital Experience

Posted on January 18, 2018

A. Alhefdhi1,2, M. Almarghoub1, B. Aladrees1, S. AlSani1, O. Almalik1,2, A. Alhefdhi1,2  1King Faisal Specialist Hospital & Research Center,General Surgery/Breast And Endocrine Surgery,Riyadh, RIYADH, Saudi Arabia 2Alfaisal University,General Surgery/Breast And Endocrine Surgery,Riyadh, RIYADH, Saudi Arabia

Introduction:  Breast cancer is a rare malignant tumor in males. This study aimed to investigate the clinicopathological characteristics of those patients in Saudi population.

Methods:  A 15-year retrospective review conducted, including all males diagnosed with breast cancer at a single institution.

Results: Forty-six cases were identified with a mean age of 58±13 years. The majorities were Saudi 40(87%), married 43(93.5%), and live in the central region of the Saudi Arabia 28(61%). Fifty-three (93.5%) cases presented with a palpable mass, and 2(4.4%) cases presented with nipple discharge. The majority has IDC 45(97.8%). ER was positive in 43(93.5%) patients, PR was positive in 37(80.4%) patients, and Her-2 was positive in 4(8.7%) patients. Regarding the tumor stage; 27(58.9%) had T4, 12(26%) had T2, 4(8.6%) had T1, and 3(6.5%) had T3. Moreover, 33(71.7%) had intermediate grades, 8(17.4%) had high grades, and 5(10.9%) had low grades. On presentation 16(34.8%) cases presented with distant metastases, which were mainly to bone and lung in 7(15.2%) cases. Forty-four (95.6%) received hormonal-therapy, 22(47.8%) received chemotherapy, and 19(41.3%) radiotherapy. Thirty-eight (82.6%) patients underwent surgical intervention; among them 31(67.4%) were therapeutic and 7(15.2%) were palliative. Twenty-nine (63%) patients underwent modified radical mastectomy, 8(17.4%) underwent simple mastectomy with SLNB, and 1(2.2%) patient underwent lumpectomy and axillary lymph node dissection. The local recurrence rate was 2.6% with a mean follow-up of 45±32 months. 

Conclusion: Based on our data; in our population the majority of males with breast cancer have IDC with positive estrogen receptors, and they usually present late.

 

43.13 Can Preoperative Thyroglobulin level Predict Thyroid Cancer in Atypia Lesion of Thyroid Nodule?

Posted on January 18, 2018

A. Alhefdhi1,2, T. AlTayyar1, M. Alshehri1,2, S. Alqahtani3, S. ALSobhi1,2, A. Alhefdhi1,2  1King Faisal Specialist Hospital & Research Center,General Surgery/Breast And Endocrine Surgery,Riyadh, RIYADH, Saudi Arabia 2Alfaisal University,General Surgery/Breast And Endocrine Surgery,Riyadh, RIYADH, Saudi Arabia 3Al Majmaah University,Al Majmaah,Al Majmaah, RIYADH, Saudi Arabia

Introduction:  Atypia of Undetermined Significance (AUS) and Follicular Lesion of Undetermined Significance (FLUS) is a heterogeneous group, in which it is difficult to classify as benign, suspicious or malignant. This study aimed to identify any correlation between patients’ demography (age, gender), ultrasound variables, nodule size, preoperative serum thyroglobulin (Tg), and anti-thyroglobulin antibodies (TgAb) levels and the final pathology (benign vs. malignant).

Methods:  A 6-year retrospective review conducted, including all patients diagnosed with AUS or FLUS at a single institution.

Results: Fifty cases were identified with a mean age of 41±12 years. The majorities were females 35(70%). The mean size of the largest thyroid nodule based on the preoperative ultrasound was 38±24mm. Moreover, the median value of the serum TG, and TgAb were 106 (0.4-3385) ug/L, and 16(9-4100) U/ml retrospectively. The mean of the thyroid stimulated hormone (TSH) was 1.83±1.2 mU/L.  The majority of the final pathology on 28(56%) cases demonstrated malignancy, and 22 (44%) cases showed benign pathology. There was no difference between those who have a benign pathology or the malignant pathology in form of age, gender, TG, TgAb, and TSH levels, or the preoperative size of the thyroid nodule. 

Conclusion: Based on our data; in our population; almost half of the patients who found to have AUS or FLUS from the thyroid nodule FNA, found to have a malignancy in the final pathology report.